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  CONDITION  Nonsteroidal Anti-inflammatory Drug (NSAID)-related Urticaria and Angioedema Overview and Recommendations  Background  Nonsteroidal anti-in!ammatory drug (NSAID)-related urticaria and angioedema is a drug ●  hypersensitivity response characterized by acute urticaria, angioedema, and/or anaphy laxis after exposure to aspirin or other NSAIDs.  ● NSAID-related urticaria and angioedema reactions include 3 characterizable types :  NSAID-induced urticaria or angioedema (NIUA) is the most common type. Symptoms ⚬  of NIUA usually occur within 1 hour of drug exposure, ranging up to about 6 hours af ter exposure to drug. NIUAA is a nonimmunologically mediated hypersensitivity reac tion related to cyclooxygenase-1 (COX-1) inhibition.  NSAID-exacerbated cutaneous disease (NECD) occurs in patients with underlying ⚬  chronic urticaria. Symptoms of NECD may occur within 30-60 minutes of drug expo sure. NECD is a nonimmunologically mediated hypersensitivity reaction related to COX-1 inhib