CONDITION Nonsteroidal Anti-inflammatory Drug (NSAID)-related Urticaria and Angioedema Overview and Recommendations Background Nonsteroidal anti-in!ammatory drug (NSAID)-related urticaria and angioedema is a drug ● hypersensitivity response characterized by acute urticaria, angioedema, and/or anaphy laxis after exposure to aspirin or other NSAIDs. ● NSAID-related urticaria and angioedema reactions include 3 characterizable types : NSAID-induced urticaria or angioedema (NIUA) is the most common type. Symptoms ⚬ of NIUA usually occur within 1 hour of drug exposure, ranging up to about 6 hours af ter exposure to drug. NIUAA is a nonimmunologically mediated hypersensitivity reac tion related to cyclooxygenase-1 (COX-1) inhibition. NSAID-exacerbated cutaneous disease (NECD) occurs in patients with underlying ⚬ chronic urticaria. Symptoms of NECD may occur within 30-60 minutes of drug expo sure. NECD is a nonimmunologically mediated hypersensitivity reaction related to COX-1 inhib